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In addition, a cardiovascular outcome trial (CVOT) was also specifically carried out, the PIONEER 6, to evaluate cardiovascular events in a larger population using oral semaglutide [40]
But study participants taking the drug still lost significantly more weight than those under the same conditions who received a placebo
If rapid pain relief is required, this minor delay is unlikely to pose problems for most individuals
In this current network meta-analysis, we evaluated 23 CVOTs, including the most recently published trials AMPLITUDE-O and EMPEROR-P
However, there is limited experience in patients with severe renal impairment or end-stage renal disease, so caution is advised
