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From 2020 to July 6 of this year, the agency received five reports of suspected adverse drug reactions involving semaglutide associated with "suicidal and self-injurious behaviour." The reports came through its Yellow Card scheme for collecting and monitoring safety concerns such as side-effects from medicines
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This can occur because GLP-1 medications influence digestive and hormonal signaling that indirectly affects saliva flow

The authors caution that SELECT is not a primary prevention trial so that the data cannot be extrapolated to all adults with overweight and obesity to prevent major adverse cardiovascular events
