eli lilly retatrutide trial VisualAbstract: reduces body weight by 17.5% in patients with obesity Eli Lilly and Company's Retatrutide

Sources Mehrtash, F., Dushay, J., & Manson, J

The reaction was allowed to proceed for 25 min and terminated by extraction using 500 mg Waters HLB cartridges preconditioned with methanol followed by water and 50 mM ammonium acetate pH 8

Several factors affect how the skin responds, including: Age Genetics Sun exposure Smoking history Collagen production Amount of weight lost Speed of weight loss For patients with mild skin laxity, non-surgical treatments may help stimulate collagen and improve skin quality

A 2025 head-to-head clinical trial comparing FDA-approved tirzepatide to FDA-approved semaglutide for obesity found that tirzepatide produced greater reductions in body weight over 72 weeks

For complete instructions, see our guide on injecting tirzepatide with a syringe