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Further clinical evidence is needed to verify the effects of GLP-1R agonists on cognitive function and pathology in AD patients

In April 2025, the National Health Commission officially included "Healthy Weight Management Action" in the "Healthy China 2030" initiative

A meta-analysis of five randomised placebo-controlled trials of liraglutide in type 1 diabetes validated these findings and additionally demonstrated no association of liraglutide with severe hypoglycaemia or DKA [55]
The results showed that all three doses of tirzepatide led to more significant HbA1c reductions than 1mg of semaglutide

For these comparisons, we considered visits where AIDA recommends a treatment intensification (increase dose, substitute or add medications)
