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GLP-1 may nevertheless also directly inhibit glucagon secretion, because -cell-specific GLP-1R KO mice have elevated non-fasting glucagon levels relative to wildtype controls and female -cell-specific GLP-1R KO mice are mildly glucose intolerant with increased secretion of glucagon upon peripheral administration of glucose [607]

However, this may vary depending on the nature of the fused biologic

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The present metaanalysis aims to summarize all the evidence from randomized trials on the effects of GLP1RA on the incidence of different malignancies