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Participants in the SGLT2i group were less likely to require admission to hospital for any reason than those in the GLP-1 RA group (RR 0.59 [95% CI 0.46, 0.76] p 0.0001)

A healthy microbiome is crucial for GLP-1 production as this hormone is synthesized in your gut

For now, though, taking what WADA deems a shortcut in training can contribute to a substance landing on the banned list

54 This trial emphasized that orforglipron might provide an alternative to injectable GLP-1 receptor agonists and oral semaglutide, with the prospect of less burdensome administration to achieve treatment goals in diabetics

For patients also taking insulin or sulfonylureas, medication adjustments may be necessary to prevent hypoglycemia if food intake decreases significantly