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can i mix semaglutide and tirzepatide Switching to TrimRX | Semaglutide vs Tirzepatide:
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Starting Semaglutide: What to Expect for Blood Pressure Changes Blood pressure typically begins declining within the first 24 weeks of semaglutide treatment, though the most significant drops usually occur between weeks 8 and 16 as weight loss accelerates

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Y.LiX.et al (2021)
This makes it one of the most effective weight loss medications available