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Clinical trials show tirzepatide producing slightly greater average weight loss, with participants losing 15 to 21 percent of body weight compared to 15 to 17 percent with semaglutide

Effective January 1, 2025, Independence Blue Cross (IBX) will no longer offer coverage for drugs including glucagon-like peptide-1 receptor antagonist (GLP-1) and non-glucagon-like peptide-1 receptor antagonist (non-GLP-1) indicated for and prescribed solely for weight loss in the absence of other FDA-approved clinical indications