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Discovery of GLP-1 Although GIP was isolated through classical peptide purification and protein sequencing methodology, the discovery of the GLP-1 sequence stemmed from the application of recombinant DNA approaches developed in the laboratories of Stanley Cohen, Paul Berg, and Herb Boyer in the early 1970s

How Corticosteroids Affect Weight and Appetite Corticosteroids like prednisone increase appetite and promote fat storage by altering glucose metabolism and stimulating hunger signals in the brain

Based on these reports, the impairment of synaptic function and synaptic transmission and the loss of synaptic density proteins are widely observed in the depressive brain ( Figure 2 )