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Chronic administration of exendin-4 or liraglutide has been shown to enhance hippocampal neurogenesis, reduce anxiety and depression-like behaviors, and attenuate neuroinflammatory cascades through downregulation of IL-6 and TNF- [63]

A meta-analysis of five randomised placebo-controlled trials of liraglutide in type 1 diabetes validated these findings and additionally demonstrated no association of liraglutide with severe hypoglycaemia or DKA [55]

Study 8 was a 72-week trial that enrolled 1,407 patients with obesity (BMI greater than or equal to 30 kg/m2), patients with type 2 diabetes mellitus were excluded

Aroda, VR, Bain, SC, Cariou, B, et al