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How Long Does Tirzepatide Diarrhea Last and What to Expect Most patients experience tirzepatide-related diarrhea for 2-6 weeks, though individual timelines vary widely based on dose, metabolism, and gut sensitivity

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SURPASS-CVOT was a randomized, double-blind, active-comparator, noninferiority Phase 3 trial in 13,299 adults with type 2 diabetes and established atherosclerotic cardiovascular disease