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Prospective studies, such as the UK Prospective Diabetes Study (UKPDS) demonstrated that T2D is a progressive disease that worsens over time, whatever the pharmacological management used to reduce daily glucose excursion

Based on these reports, the impairment of synaptic function and synaptic transmission and the loss of synaptic density proteins are widely observed in the depressive brain ( Figure 2 )

Exenatide treatment ameliorates these morphological alterations and inhibits the mitochondrial apoptotic pathway by suppressing cytochrome c release and favorably modulating the expression of pro-apoptotic (Bax, caspase-3) and anti-apoptotic (Bcl-2) proteins, thereby protecting RGC-5 cells from hyperglycemic injury [43]

Ex-4 had 53% structural similarity with GLP-1 but could activate GLP-1 receptors (GLP-1R), and its longevity in the plasma was longer than that of GLP-1 [15]

& Liu, D
