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Description

In a Phase 2 clinical trial involving adults with obesity, participants receiving the highest dose achieved an average weight reduction approaching 24% at 48 weeks , among the largest weight losses reported with a medication

Code availability The pre-trained ensemble of deep multi-task neural-network models with weights used to draw the presented inferences, the code for the ensemble training, and the module for model-guided peptide sequence optimization together with all data used in this study are freely available for download from the online repository The repository contains IPython notebooks tutorials that demonstrate how to use the software

Bone microstructure High-resolution peripheral quantitative computed tomography (HR-pQCT) revealed declines in vBMD at both the radius and tibia, with particularly pronounced reductions in total and cortical vBMD at the tibia in postmenopausal women