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First, Pendulum performed a consumer study of 274 people and found that the supplement significantly reduced cravings based on Food Craving Inventory (FCI) scores

Phentermine should not be used during pregnancy or while breastfeeding

In a dosing ranging study, 472 individuals who are overweight without diabetes were randomised and 72% completed 26 weeks of treatment

This claim is based on the results of clinical trials that evaluated the effects of the weight loss medications offered through the Ro Body Program, including Zepbound (tirzepatide) and Wegovy (semaglutide)

Development of a formal clinical guideline, including specific dose-titration protocols, chronic kidney disease (CKD) considerations, and polypharmacy interactions, remains beyond the scope of this review and would require a dedicated systematic investigation