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In CagriSema trials, the proportion reaching this threshold was lower approximately 24% in REIMAGINE 2 (which included type 2 diabetes patients) and an estimated 35-40% in REDEFINE 1

Currently, the existing data from humans and rodents are therefore inconclusive as to whether pre-pregnancy treatment with GLP1RAs that is stopped before conception results in lasting improvements/detrimental effects to maternal health during pregnancy

Appetite typically returns within 24 weeks

Consequently, the metabolic action of incretins has served as the basis for multiple strategies in the treatment of type 2 diabetes

Discontinuations due to gastrointestinal issues were also higher in the semaglutide group