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The relative risk of symptomatic cholelithiasis was 1.6, 0.9, and 1.4 in liraglutide, dulaglutide, and semaglutide with number needed to harm of 3.14, 16.67, and 5.56, respectively

The results prompt safety concerns for GLP-1RAs, especially with high dose administration, regarding gastrointestinal adverse events

GLP-1 plays an important role in regulating appetite by creating the sensation of feeling full after a meal

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