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The glucagon component increases energy expenditure and hepatic fat oxidation

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A 2025 Cochrane review of 18 studies confirmed that semaglutide (Wegovy/Ozempic) results in approximately 10.7% greater weight loss compared to placebo, with high-certainty evidence [6]

Hamlet Gasoyan, lead study author and a researcher with Cleveland Clinics Center for Value-Based Care Research

Specifically, GLP-1 agonists increased expression of the progesterone receptor, and the combination of the two agents resulted in more pronounced cell death as compared to a single agent alone