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Nature 626 , 246 (2024)
Wang CF et al
Patients with T2DM experience a significant decline in the incretins functional properties which causes delayed and reduced insulin release after glucose administration and impairs glucose tolerance [12,13,14]
In the cardiovascular system, GLP-1R is known to exist not only on cardiomyocytes and endothelial cells, but also in the autonomic nervous system, Figure 3 suggests that GLP-1R may have direct and indirect effects on the heart and blood vessels
A similar finding was reported in an analysis of adverse drug reactions using the World Health Organization pharmacovigilance database VigiBase (92)
