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In conclusion, the paper provides evidence that the reduction of GLP-1+ cells is a general feature of ileal and colonic inflammation in mice and humans and is likely due to altered epithelial differentiation driven by changes in cellular metabolism, particularly mitochondrial dysfunction.

Of note, combination therapy faces significant barriers, including safety concerns in older or frail individuals, underutilisation in disadvantaged populations, while economic challenges may further hinder the accessibility of these therapies

Teva launches first generic GLP-1 drug in U.S., pricing liraglutide at $469.60 for two-pack, $704.40 for three-pack