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Mental stress should be addressed among individuals with obesity, as chronic stress may promote obesity development through the sympathetic nervous system and hypothalamic-pituitary-adrenal axis activation that elevates cortisol levels, interferes with insulin sensitivity, promotes energy storage, and creates food cravings for ultra-processed comfort foods [180] GLP-1s may act both centrally and peripherally to reduce these downstream impacts of chronic stress and obesity and alter food reward pathways in positive ways [124]

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Compounded medications contain the same active ingredients as brand-name options but are prepared by specialized pharmacies

Under the negotiated terms, the government pays $245 per month for GLP-1 medications, a fraction of the $1,000-plus list price

Obesity is a known risk factor for VTE responsible for between 10-30% of all cases