can glp 1 cause diabetes GLP‑1 Drugs: Obesity & Treatment Fight Mechanism by which excessive circulating

Description

These agents further optimize glucose utilization by activating glycolytic enzymes such as hexokinase and phosphofructokinase, thereby enhancing glycolytic flux (90)

One potential mechanism could be increased prevalence of NAION risk factors in patients starting GLP-1RA or that sudden and rapid decline in blood glucose could increase the risk of diabetic papillopathy or worsened DR

Until those data arrive, claims about meaningful, reproducible benefits should be treated as hypotheses

Resistance training, adequate protein intake (1.2-1.6 g/kg/day, adjusted to actual body weight), and consideration of complementary compounds that support lean mass, such as tesamorelin for GH-mediated anabolic support or CJC-1295/Ipamorelin for broader GH optimization, become increasingly important with longer treatment duration