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20 Semaglutide and liraglutide had significantly higher reporting odds ratios (RORs) compared to metformin or insulin for suicide ideation, depression/suicidal, suicide attempt, and completed suicide

Diabetic Retinopathy Considerations Rapid improvement in blood glucose control, particularly with semaglutide, has been associated with temporary worsening of diabetic retinopathy in some patients

However, such results must be interpreted cautiously, as the small sample size and short study durations preclude comment on the long-term effects and safety of GLP-1 RAs in the treatment of psoriasis, ultimately limiting the ability to draw definitive, robust conclusions

Its used for weight loss in adults who have obesity or overweight, and should be paired with healthy lifestyle changes

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