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It plays a role through a specific GLP-1 receptor (GLP-1R) distributed in many organs or tissues and participates in the regulation of glucose homeostasis in the body

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proposed that semaglutide may mitigate hepatic steatosis and hepatocellular ballooning in HFD-induced NAFLD mice through the modulation of the AMPK/mTORC1 signaling pathway [31], similarly to the above-mentioned effect of liraglutide [16]

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Currently, NICE guidance (NG71) for Parkinson's disease does not recommend GLP-1 receptor agonists for treating this condition