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FIGURE 3 By patient age group, the median onset time for cholecystitis and cholelithiasis varied across different GLP-1 RAs

Retatrutide targets three hormone receptors including glucagon whilst Mounjaro targets two, potentially offering greater weight loss and metabolic benefits though direct comparison studies in PCOS are still needed

We don't fully understand the weight loss-independent mechanisms through which GLP-1 reduces inflammation is it through the brain, or via T cells, or other pathways