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4 For patients with an entry A1C of 7.5% or higher, the algorithm recommends dual therapy consisting of metformin plus an additional antihyperglycemic agent

This mechanism may be particularly relevant in BED because binge eating is associated with impaired satiety

Samuel Seidu: methodology, data curation, formal investigation, writingreview and editing

In fact, indirect inhibition of GLP-1 secretion via sc injection of octreotide, a somatostatin analog, enhances computer mouse clicks for chocolate rewards in individuals who underwent RYGB surgery but not in obese non-operated controls, suggesting that RYGB surgery influences the effects of GLP-1 signaling on food-motivated responses [99]

The FDA continues to monitor the safety of semaglutide-containing medications