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Nausea typically peaks during the first few weeks after starting Zepbound or increasing the dose, then gradually improves as your body adjusts to the medication

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The dosing protocols that produced clinical trial results were built on this precision

Furthermore, it could exacerbate certain adverse effects associated with Mounjaro, including nausea and dizziness

This pharmacokinetic profile provides a natural taper period, though patients should understand that appetite suppression and glycemic benefits will progressively decline during this window