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36 Collectively, these data support a growing body of evidence of the promising role of GLP-1RAs in retinal health

Considerando, inoltre, che il paziente affetto da DMT2 spesso presenta numerose comorbidit strettamente correlate allinfiammazione cronica, limpiego dei GLP1RAs dovrebbe essere considerato gi in una fase precoce della malattia, in modo da prevenire, o quantomeno rallentare, linsorgenza di complicanze croniche che impattano notevolmente sulla qualit di vita della persona e sulle spese economiche sanitarie

Chronic weight management in adults with obesity or overweight with at least one weight-related condition (such as high blood pressure, type 2 diabetes or high cholesterol) Treatment of moderate to severe obstructive sleep apnea (OSA) in adults with obesity

Additionally, the GLP-1R/glucose-dependent insulinotropic polypeptide receptor (GIPR) dual agonist tirzepatide can induce weight loss of 10%20%, and the results of the ongoing SURPASS-CVOT trial may provide more clarity on whether weight loss itself is an independent driver of CV protection (74)