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High salt and high glucose increased p-Nedd4-2 and ENaC levels in cultured distal tubules, which was inhibited by LINA or glucagon like peptide-1 (GLP-1), but there were no additive effects of LINA on GLP-1, the latter of which was blocked by GLP-1 receptor agonist
Flint and colleagues examined the effects of acute GLP-1 infusion on sensations of hunger and satiety in healthy human volunteers
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"He was having loose, watery, large-volume bowel actions every one to two hours, including overnight, and losing what we estimated to be eight litres of fluid a day
