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Quick Answer: GLP-1 receptor agonists do not directly increase fracture risk, but substantial weight loss during treatment may indirectly reduce bone mineral density at weight-bearing sites

Established pharmacological options including acamprosate, naltrexone, and nalmefene remain the evidence-based first-line treatments

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Eating a well-rounded diet with sufficient calories and nutrients supports energy levels

"Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor"