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References 1.Li Z.S., Schmauss C., Cuenca A., Ratcliffe E., Gershon M.D

Most doctors will have patients start with low doses to reduce any potential GI side effects, then increase the dose based on their response and tolerance

Elevated HbA1c, insulin resistance, and inflammatory markers often indicate longer therapy may support deeper metabolic improvement

Med 112, 534543 [DOI] [PMC free article] [PubMed] [Google Scholar] 48.Sonoda N, Imamura T, Yoshizaki T, Babendure JL, Lu JC, and Olefsky JM (2008) Beta-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic beta cells

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