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The most common microdosing methods include staying on the starting dose for a longer duration, reducing injection frequency by counting the clicks, or splitting and diluting pens

First-choice options are typically the most effective agents and are in line with options advised by NICE guidelines unless otherwise stated

Injectable GLP-1 medications generally have no direct interaction with levothyroxine, though delayed gastric emptying may affect absorption timing

[3][6] NLEM 2022 already emphasises the growing burden of diabetes and the need for key diabetes drugs in public systems, and official documents acknowledge GLP-1 RAs as important options.[15] If liraglutide and semaglutide formulations used for diabetes are eventually brought under price control, MRPs could drop by another 2030% beyond current generic competition, especially where innovator prices remain high

In September 2025, researchers at UCLA published a study in ACR Open Rheumatology (Kellner and colleagues)