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Owing to its high surface area and metabolic activity, trabecular bone is highly sensitive to rapid hormonal and nutritional fluctuations, making it initially more susceptible to CR-induced remodeling alterations

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Similarly, cutting or modifying patches to adjust dosing is dangerous and should never be attempted, as this can cause rapid, uncontrolled drug release and potential overdose
Patients should maintain an updated medication list including tirzepatide dose and frequency, and carry this information to all medical appointments
