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This effect is consistent with what has been observed with other GLP-1 based compounds and is thought to reflect a combination of weight-mediated reduction in vascular resistance and direct vascular effects of GLP-1 receptor activation

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DPP-4i: dipeptidyl peptidase-4 inhibitor
doi: 10.1016/j.molmet.2018.02.008

By this point, the body has had sixteen weeks to progressively adapt to triple-agonist activity
