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2 As with most of the beneficial effects of GLP-1 in type-2 diabetic patients, the exact mechanism by which it induces satiety is not known and more research is underway

In most clinical trials, participants who lost the most weight combined medication with changes to diet and regular exercise

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Beneficial Endocrine but Adverse Exocrine Effects of Sitagliptin in the Human Islet Amyloid Polypeptide Transgenic Rat Model of Type 2 Diabetes: Interactions with Metformin