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showed that reduction of atherosclerosis and systemic inflammation in response to semaglutide was preserved in mice lacking the GLP-1R in endothelial and hematopoietic lineage cells (11)

Common side effects include mild to moderate GI symptoms, but more serious health risks or complications may also occur in certain groups of people

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Fortunately, GLP1 medications are now FDA-indicated for multiple indications beyond weight management and diabetes, including: Major cardiovascular event (heart attack and/or stroke) risk reduction in adults with cardiovascular disease and overweight or obesity Metabolic dysfunctionassociated steatohepatitis (MASH) Moderate to severe obstructive sleep apnea (OSA) in adults with obesity When one medication can address multiple conditions, it simplifies care and reduces polypharmacy