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Some research suggests that chronic high-dose L-carnitine supplementation may increase TMAO levels via gut bacteria metabolism, and elevated TMAO has been associated with increased cardiovascular risk in observational studies

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Coverage Issues: Medicare For years, Medicare has been prohibited from covering weight loss drugs because of the Medicare Prescription Drug, Improvement, and Modernization Act of 2003, which explicitly bars coverage of drugs for weight loss

(2018) 236:R2942
This can be particularly beneficial for individuals who are overweight and have other health issues related to their weight, such as high blood pressure or cholesterol
