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Lancet (London, England

From a pharmacokinetic perspective, besides increased gastric emptying, obesity has been suggested to modulate CYP gene expression, and increased fat mass may result in an increased Vd of lipophilic drugs.210,211 The weight loss effects from GLP-1 RA treatment may reverse these changes and alter the pharmacokinetics of co-administered lipophilic drugs by decreasing the Vd (Figure 3)

Supresa Saffron Extract: Standardized to 0.3% safranal, this extract has been associated with a 69% decrease in hunger and a 55% reduction in snacking events over an eight-week period

This is not believed to be a direct drug effect but rather a consequence of the rapid and significant weight loss induced by potent GLP-1 agonists, which can alter bile acid composition and gallbladder motility

We reported the full search strings in Table S1