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This can happen for a variety of reasons, including genetics, gut imbalances, or chronic health issues

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One year after treatment cessation, participants in the exercise-alone and exercise-liraglutide groups reported the highest levels of moderate-to-vigorous physical activity (MVPA), with median self-reported values of 240 and 225 minutes/week, respectively, compared to 150 minutes/week in placebo and only 30 minutes/week in the liraglutide-alone group [15]

92 The analysis showed no difference in all-cause mortality among those with baseline HF when compared to placebo (HR 1.05