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Available from: 6.Zhu L, She ZG, Cheng X, et al

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During the titration period, doses of metformin and glimepiride were to be increased up to 2,000 mg/day and 4 mg/day, respectively

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Genetic Variants in Peptide Metabolism Pathways Genetic variants in the GLP1R, GIPR, FTO, and MC4R genes influence how individuals metabolize GLP-1 agonists and respond to appetite suppression and weight loss

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Start Early and Sip Often Begin your day with a glass of water and aim to drink consistently throughout the day rather than chugging large amounts at once, which can worsen nausea

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Stool softeners (docusate): May help but have limited evidence for efficacy

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