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2- Improvements in HbA1c for Diabetes Management: Among participants with type 2 diabetes, retatrutide demonstrated substantial improvements in glycemic control, reducing HbA1c levels by 1.3% to 2.0% [4] after 24 to 26 weeks of treatment

174 Recently, metformin has been hypothesized to be used as an adjunct treatment in type 1 diabetes to limit the insulin dose and to prevent the long-term difficulties of diabetes including weight gain, atherosclerotic progression, as well as elevated cholesterol levels of LDL

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This means that if youre doing well on a lower dose, theres no need to increase it

For patients considering GLP-1 medications or currently taking them, its worth having a conversation with your healthcare team about muscle health