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Increasing the dose slowly over time helps to minimize the frequency and severity of GI symptoms

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Alcohol independently irritates the stomach lining and can trigger or worsen nausea, vomiting, reflux, and dehydration

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doi: 10.2337/dc15-2237

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Dehydration represents an important factor, as GLP-1 medications can cause nausea, vomiting, and diarrhea, particularly during dose escalation, leading to volume depletion

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