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Therapies based on glucagon-like peptide-1 (GLP-1) reduce rates of cardiovascular and chronic kidney disease in people with type 2 diabetes and/or obesity, with ongoing clinical trials investigating their effects in people with metabolic liver ...

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2024 Jan;38(1):117-130

Lilly is counting on next-generation incretin medicines like Retatrutideas well as its oral GLP-1 Orforglipronto eventually pick up the torch from its current diabetes and obesity mainstays Mounjaro and Zepbound, both of which are underpinned by Lillys dual GIP/GLP-1 receptor agonist Tirzepatide.

Liraglutide is well tolerated, sustains weight loss over 2 years and improves cardiovascular risk factors.