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Peripherally, GLP-1 RAs delay gastric emptying, lower levels of the hunger hormone ghrelin, and improve glucose and lipid metabolism by enhancing insulin secretion, reducing glucagon release, and promoting fat utilization
[DOI] [PubMed] [Google Scholar] 49.Perello M, Raingo J
GLP-1 is produced by the tissue-specific cleavage of proglucagon into several smaller peptides in the L-cells of the intestinal mucosa and GIP is synthesized by K cells found in the intestinal mucosa ( Figure 19 - 1 )
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