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Peripheral IR may also exacerbate central insulin resistance, disrupting dopaminergic signaling and further impairing brain function [49]

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Glucose-dependent insulin secretion and suppression of inappropriately elevated glucagon

In a 72-week trial involving over 2,500 adults with obesity or overweight and at least one weight-related condition, participants lost an average of over 18% of their initial body weight

Its not listed specifically because the label tracks formal adverse events reported in the major clinical trials for FDA approval, like nausea, [acid] reflux, belching, constipation, and delayed gastric emptying, said Dr