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Insulinotropic potency of GLP-1 decrease in T2DM
Receptors of these incretins, GLP-1R and GIPR are G protein-coupled receptors (GPCR) that activate the classical signaling cascade through Gs and adenylate cyclase (Adcy), leading to increased cAMP production [6,7]
doi: 10.1111/j.1365-2036.2006.02938 86 TanaC.UmesakiY.ImaokaA.HandaT.KanazawaM.FukudoS
Besides, KKAy mice were selected and divided into the Lira group and the HF feeding group
2018;8:a028977
