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Crohn's disease is a chronic inflammatory bowel condition that affects the gastrointestinal tract, causing symptoms including abdominal pain, diarrhoea, and weight changes

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[13] [14] Weight Loss and Metabolic Adaptation The concern about metabolic "damage" often stems from the well-documented phenomenon of adaptive thermogenesisthe body's natural reduction in energy expenditure that occurs with significant weight loss, regardless of the method used

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Together, these mechanisms highlight the bidirectional interaction between gut and liver and support therapeutic strategies targeting microbiota composition and intestinal barrier integrity in MASLD