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Description
The allylamide intermediate was isomerized in the presence of RhCl 3 without any epimerization of the acid/base-labile stereogenic center adjacent to the nitro group on the piperidinone ring
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After 68 weeks, adults lost about 35 lbs (15.9 kg) in studies, on average
This pattern is well-established across the drug class and is thought to reflect the gut's gradual adaptation to altered motility signals
This condition is known as gastroparesis, and it can have unpleasant consequences if left untreated
