tirzepatide and autoimmune disorders GLP1, GIP & Inflammation:What Semaglutide & Really Do Do Anti-Obesity Medications Benefit Autoimmune

Zostavax , a live-attenuated VZV vaccine approved for the same indication, has been available since 2006.1,2 HERPES ZOSTER Following primary infection, VZV persists in a latent form in sensory ganglia

GLP1-R is a class B G protein-coupled receptor,25 and its expression has been reported in the cerebral cortex, especially the occipital and frontal lobes, hypothalamus, and thalamus, whereas lower levels are found in the caudate putamen, globus pallidus, and hippocampus.21 GLP-1 and its RA cross the bloodbrain barrier, with exendin-4 considered as one of the best based on the rate of brain influx, percentage of reaching the brain that accumulates in the brain parenchyma, and percentage of the systemic dose taken per gram of brain tissue.8 Small amounts of GLP-1 may also be produced by preproglucagon neurons, located in the nucleus tractus solitarii of the brainstem26,27 and projected to other brain regions, such as the nuclei of the hypothalamus, including the arcuate and paraventricular nuclei.28 In the case of diabetes or obesity-related IR, GLP-1 secretion in the brain29 and peripheries30 may be impaired, which may contribute to the pathogenic change in neurodegeneration and cognitive decline

If patients suspect hair loss may be a side effect of tirzepatide, they should report this through the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk)

1mL under the tongue, 30 min before bypasses first-pass metabolism for rapid effect

These are not theoretical concerns or rodent extrapolations