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Understanding the Full Safety Profile Every potent medication comes with a trade-off
no hepatic safety signal has been observed across the orforglipron clinical program, distinguishing it from the discontinued Pfizer oral GLP-1 candidates lotiglipron and danuglipron, both of which were terminated due to liver toxicity concerns
Request clarification about the injection frequency (typically once weekly), how doses are adjusted over time, and what happens when you reach your target dose
Read the full journal article at JAMA, or read on for highlights from the study
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