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In addition to the direct impact on the proportion of gut bacteria, GLP-1RAs were found to upregulate tight junction proteins in the intestinal mucosa, which helps prevent the translocation of bacteria to the blood

Hormonal dysregulation, insulin resistance, chronic inflammation, disrupted appetite signaling, sleep disorders, and genetic predisposition all play significant roles in why losing weight is hard and why keeping it off is even harder without medical support

95% CI, 2.1-3.7)

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Furthermore, almost all available evidence reflects the acute effects of GLP-1 manipulation on reward